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** The Web's Daily Resource for ALS News
------------------------------------------------------------


** In the 01/09/2026 edition:
------------------------------------------------------------

*
** Aperture advances RNA-targeting treatment for ALS (https://alsnewstoday=
=2Eus5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3Dba6aa2=
ff60&e=3D006462e992)
------------------------------------------------------------


*
** The ongoing turnover of ALS caregivers is challenging to manage (https:=
//alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee7=
92&id=3D27223349cf&e=3D006462e992)
------------------------------------------------------------


*
** Shionogi strengthens rare disease strategy with planned Radicava deal (=
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3De7484f6af8&e=3D006462e992)
------------------------------------------------------------





** Aperture advances RNA-targeting treatment for ALS (https://alsnewstoday=
=2Eus5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3Df80838=
1ddb&e=3D006462e992)
------------------------------------------------------------
By Michela Luciano=2C PhD on 01/09/2026
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D99e8ab08de&e=3D006462e992

Aperture Therapeutics said it is advancing its RNA-targeting therapy APRTX=
-003 as a potential treatment for amyotrophic lateral sclerosis (ALS). The=
 therapy=2C currently in preclinical development=2C is designed to reduce=
 the production of matrix metalloproteinase-9 (MMP-9) by targeting its tem=
plate RNA molecule. When overactive=2C this enzyme may lead to neuroinflam=
mation and nerve cell damage in ALS. [=E2=80=A6]

The post Aperture advances RNA-targeting treatment for ALS (https://alsnew=
stoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D=
a1161458df&e=3D006462e992) appeared first on ALS News Today (https:/=
/alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee79=
2&id=3De62a03b2c5&e=3D006462e992) .
Continue Reading (https://alsnewstoday.us5.list-manage.com/track/click?u=
=3D52c64784d386bd00ea57ee792&id=3D303a7817b6&e=3D006462e992)



** The ongoing turnover of ALS caregivers is challenging to manage (https:=
//alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee7=
92&id=3D6b6abd6c72&e=3D006462e992)
------------------------------------------------------------
By Kristin Neva on 01/08/2026
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D34184e1817&e=3D006462e992

=E2=80=9CI feel like crying=2C=E2=80=9D I wrote in my journal after a seco=
nd caregiver decided to leave in December. =E2=80=9CI can do 18 hours a da=
y on duty=2C but I need to sleep sometimes.=E2=80=9D For a few months=2C w=
e had had a reliable team of nighttime caregivers for my husband=2C Todd=
=2C who has ALS. But just [=E2=80=A6]

The post The ongoing turnover of ALS caregivers is challenging to manage (=
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3Da53a5daf84&e=3D006462e992) appeared first on ALS News=
 Today (https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d=
386bd00ea57ee792&id=3D16c8fe5c40&e=3D006462e992) .
Continue Reading (https://alsnewstoday.us5.list-manage.com/track/click?u=
=3D52c64784d386bd00ea57ee792&id=3D3a6ce1c648&e=3D006462e992)



** Shionogi strengthens rare disease strategy with planned Radicava deal (=
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D1548707f72&e=3D006462e992)
------------------------------------------------------------
By Margarida Maia=2C PhD on 01/08/2026
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D6601126c63&e=3D006462e992

Tanabe Pharma plans to establish a new U.S.-based company to hold the glob=
al rights to Radicava and Radicava ORS=2C two edaravone formulations appro=
ved to treat amyotrophic lateral sclerosis (ALS)=2C which Shionogi plans t=
o acquire and operate as a wholly owned subsidiary. =E2=80=9CWe are please=
d to welcome Radicava to Shionogi=2C=E2=80=9D Isao Teshirogi=2C PhD=2C Shi=
onogi=E2=80=99s president and [=E2=80=A6]

The post Shionogi strengthens rare disease strategy with planned Radicava=
 deal (https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d3=
86bd00ea57ee792&id=3De7bc3e7861&e=3D006462e992) appeared first on AL=
S News Today (https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c=
64784d386bd00ea57ee792&id=3Ddc61d42b9c&e=3D006462e992) .
Continue Reading (https://alsnewstoday.us5.list-manage.com/track/click?u=
=3D52c64784d386bd00ea57ee792&id=3D4535b01045&e=3D006462e992)



** More Recent Articles:
------------------------------------------------------------
** Finding my 'swingtime' is helping me to manage transitions with ALS (ht=
tps://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea5=
7ee792&id=3Dd39bd1bbe4&e=3D006462e992)
** Open dialogue is key to better psychological support in ALS: Study (htt=
ps://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57=
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** QRL-101 reduces motor-neuron hyperexcitability in ALS trial (https://al=
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** Range of motion exercises for ALS (https://alsnewstoday.us5.list-manage=
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** COYA 302 trial in ALS expands to Canada after regulatory nod (https://a=
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id=3D28eb2e8474&e=3D006462e992

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th: 600px !important;">
                                        <tr>
                                            <td valign=3D"top" class=3D"bo=
dyContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D"=
0" cellspacing=3D"0" width=3D"100%" class=3D"mcnTextBlock" style=3D"min-wi=
dth: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace=
: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09<!--[if mso]>
=09=09=09=09<table align=3D"left" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" width=3D"100%" style=3D"width:100%;">
=09=09=09=09<tr>
=09=09=09=09<![endif]-->
=09=09=09
=09=09=09=09<!--[if mso]>
=09=09=09=09<td valign=3D"top" width=3D"NaN" style=3D"width:NaNpx;">
=09=09=09=09<![endif]-->
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;float: left;" width=3D"100%" class=3D"mc=
nTextContentContainer">
                    <tbody><tr>

                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding-top: 0;padding-right: 18px;padding-bottom: 9px;padding-left: 1=
8px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;word-break: break-word;color: #212121;font-family: 'Helv=
etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 15px=
;line-height: 150%;text-align: left;">

                            <h3 style=3D"display: block;margin: 0;padding:=
 0;color: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Rom=
an'=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-hei=
ght: 125%;letter-spacing: normal;text-align: left;"><strong>The Web's Dail=
y Resource for ALS News</strong></h3>

<h4 style=3D"display: block;margin: 0;padding: 0;color: #212121;font-famil=
y: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C serif;font-size: 16px=
;font-style: normal;font-weight: bold;line-height: 125%;letter-spacing: no=
rmal;text-align: left;"><strong>In the 01/09/2026 edition:</strong></h4>


<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">
=09<h2 class=3D"null" style=3D"display: block;margin: 0;padding: 0;color:=
 #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C se=
rif;font-size: 17px;font-style: normal;font-weight: bold;line-height: 125%=
;letter-spacing: normal;text-align: left;"><span class=3D"mc-toc-title"><a=
 href=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784=
d386bd00ea57ee792&id=3Dcd9a77926b&e=3D006462e992" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #084c61;font-weight: normal;text-decoration: unde=
rline;">Aperture advances RNA-targeting treatment for ALS</a></span></h2>
=09</li>
</ul>
<span style=3D"font-size:16px"><span style=3D"font-family:merriweather=2Cg=
eorgia=2Ctimes new roman=2Cserif">

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">
=09<h2 class=3D"null" style=3D"display: block;margin: 0;padding: 0;color:=
 #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C se=
rif;font-size: 17px;font-style: normal;font-weight: bold;line-height: 125%=
;letter-spacing: normal;text-align: left;"><span class=3D"mc-toc-title"><a=
 href=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784=
d386bd00ea57ee792&id=3De7d98daf32&e=3D006462e992" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #084c61;font-weight: normal;text-decoration: unde=
rline;">The ongoing turnover of ALS caregivers is challenging to manage</a=
></span></h2>
=09</li>
</ul>
<span style=3D"font-size:16px"><span style=3D"font-family:merriweather=2Cg=
eorgia=2Ctimes new roman=2Cserif">

<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">
=09<h2 class=3D"null" style=3D"display: block;margin: 0;padding: 0;color:=
 #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C se=
rif;font-size: 17px;font-style: normal;font-weight: bold;line-height: 125%=
;letter-spacing: normal;text-align: left;"><span class=3D"mc-toc-title"><a=
 href=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784=
d386bd00ea57ee792&id=3De430bc68c3&e=3D006462e992" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #084c61;font-weight: normal;text-decoration: unde=
rline;">Shionogi strengthens rare disease strategy with planned Radicava d=
eal</a></span></h2>
=09</li>
</ul>
<span style=3D"font-size:16px"><span style=3D"font-family:merriweather=2Cg=
eorgia=2Ctimes new roman=2Cserif"> </span></span>
                        </span></span></span></span></td>
                    </tr>
                </tbody></table>
=09=09=09=09<!--[if mso]>
=09=09=09=09</td>
=09=09=09=09<![endif]-->

=09=09=09=09<!--[if mso]>
=09=09=09=09</tr>
=09=09=09=09</table>
=09=09=09=09<![endif]-->
            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnDividerBlock" style=3D"min-width: 100%;border-collapse: c=
ollapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;table-layout: fixed !important;">
    <tbody class=3D"mcnDividerBlockOuter">
        <tr>
            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
dding: 7px 18px 10px;mso-line-height-rule: exactly;-ms-text-size-adjust: 1=
00%;-webkit-text-size-adjust: 100%;">
                <table class=3D"mcnDividerContent" border=3D"0" cellpaddin=
g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-t=
op-width: 1px;border-top-style: solid;border-top-color: #D7D7D7;border-col=
lapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-=
adjust: 100%;-webkit-text-size-adjust: 100%;">
                    <tbody><tr>
                        <td style=3D"mso-line-height-rule: exactly;-ms-tex=
t-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                            <span></span>
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or:none; border-left-color:none; border-right-color:none; border-bottom-wi=
dth:0; border-left-width:0; border-right-width:0; margin-top:0; margin-rig=
ht:0; margin-bottom:0; margin-left:0;" />
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
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    <tbody class=3D"mcnTextBlockOuter">
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            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09<!--[if mso]>
=09=09=09=09<table align=3D"left" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" width=3D"100%" style=3D"width:100%;">
=09=09=09=09<tr>
=09=09=09=09<![endif]-->
=09=09=09
=09=09=09=09<!--[if mso]>
=09=09=09=09<td valign=3D"top" width=3D"600" style=3D"width:600px;">
=09=09=09=09<![endif]-->
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;float: left;" width=3D"100%" class=3D"mc=
nTextContentContainer">
                    <tbody><tr>

                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding-top: 0;padding-right: 18px;padding-bottom: 9px;padding-left: 1=
8px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;word-break: break-word;color: #212121;font-family: 'Helv=
etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 15px=
;line-height: 150%;text-align: left;">

                            <div style=3D"text-align: left;"></div>

<h2 class=3D"mc-toc-title" style=3D"display: block;margin: 0;padding: 0;co=
lor: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=
=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-height=
: 125%;letter-spacing: normal;text-align: left;"><a href=3D"https://alsnew=
stoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D=
9e4d767623&e=3D006462e992" target=3D"_blank" style=3D"mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #084c61;font-weight: normal;text-decoration: underline;">Aperture advanc=
es RNA-targeting treatment for ALS</a></h2>
<span style=3D"color:#033443"><em>By Michela Luciano=2C PhD on </em></span=
><em>01/09/2026</em><br>
<span style=3D"color:#212121"><a href=3D"https://alsnewstoday.us5.list-man=
age.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D035852fbc6&e=3D006462e992" title=3D"Aperture advances RNA-targeting treatment for ALS" rel=
=3D"nofollow" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust:=
 100%;-webkit-text-size-adjust: 100%;color: #084c61;font-weight: normal;te=
xt-decoration: underline;"><img width=3D"700" src=3D"https://alsnewstoday.=
com/wp-content/uploads/2025/01/LabScientist.png" class=3D"webfeedsFeatured=
Visual wp-post-image mcRssImage" alt=3D"A researcher in a lab uses a dropp=
er to apply material to a petri dish." style=3D"max-width: 100%;width: 100=
%;padding-bottom: 0;display: inline;vertical-align: bottom;border: 0;heigh=
t: auto;outline: none;text-decoration: none;-ms-interpolation-mode: bicubi=
c;" link_thumbnail=3D"1" decoding=3D"async" loading=3D"lazy" srcset=3D"htt=
ps://alsnewstoday.com/wp-content/uploads/2025/01/LabScientist.png 700w=2C=
 https://alsnewstoday.com/wp-content/uploads/2025/01/LabScientist-380x190.=
png 380w" sizes=3D"(max-width: 700px) 100vw=2C 700px" data-wp-pid=3D"96816=
" border=3D"0"></a><p style=3D"margin: 10px 0;padding: 0;mso-line-height-r=
ule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;col=
or: #212121;font-family: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=
=2C sans-serif;font-size: 15px;line-height: 150%;text-align: left;">Apertu=
re Therapeutics said it is advancing its RNA-targeting therapy APRTX-003 a=
s a potential treatment for amyotrophic lateral sclerosis (ALS). The thera=
py=2C currently in preclinical development=2C is designed to reduce the pr=
oduction of matrix metalloproteinase-9 (MMP-9) by targeting its template R=
NA molecule. When overactive=2C this enzyme may lead to neuroinflammation=
 and nerve cell damage in ALS. [&#8230;]</p>
<p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121;font-fa=
mily: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font=
-size: 15px;line-height: 150%;text-align: left;">The post <a href=3D"https=
://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee=
792&id=3D466d783850&e=3D006462e992" style=3D"mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61=
;font-weight: normal;text-decoration: underline;">Aperture advances RNA-ta=
rgeting treatment for ALS</a> appeared first on <a href=3D"https://alsnews=
today.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3Dc=
4daabf3c2&e=3D006462e992" style=3D"mso-line-height-rule: exactly;-ms-text=
-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61;font-weig=
ht: normal;text-decoration: underline;">ALS News Today</a>.</p></span>
                        </td>
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                </tbody></table>
=09=09=09=09<!--[if mso]>
=09=09=09=09</td>
=09=09=09=09<![endif]-->

=09=09=09=09<!--[if mso]>
=09=09=09=09</tr>
=09=09=09=09</table>
=09=09=09=09<![endif]-->
            </td>
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnButtonBlock" style=3D"min-width: 100%;border-collapse: co=
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00%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnButtonBlockOuter">
        <tr>
            <td style=3D"padding-top: 0;padding-right: 18px;padding-bottom=
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st: 100%;-webkit-text-size-adjust: 100%;" valign=3D"top" align=3D"center"=
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                <table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" cl=
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rtant;border-radius: 43px;background-color: #FDBA53;mso-table-lspace: 0pt;=
mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust:=
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                            <td align=3D"center" valign=3D"middle" class=
=3D"mcnButtonContent" style=3D"font-family: &quot;Helvetica Neue&quot;=2C=
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;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-siz=
e-adjust: 100%;">
                                <a class=3D"mcnButton " title=3D"Continue=
 Reading" href=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=
=3D52c64784d386bd00ea57ee792&id=3D4313b65dd5&e=3D006462e992" target=3D"_b=
lank" style=3D"font-weight: bold;letter-spacing: normal;line-height: 100%;=
text-align: center;text-decoration: none;color: #084C61;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;disp=
lay: block;">Continue Reading</a>
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</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnDividerBlock" style=3D"min-width: 100%;border-collapse: c=
ollapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust:=
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            <td class=3D"mcnDividerBlockInner" style=3D"min-width: 100%;pa=
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g=3D"0" cellspacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-t=
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lapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-=
adjust: 100%;-webkit-text-size-adjust: 100%;">
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g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09<!--[if mso]>
=09=09=09=09<table align=3D"left" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" width=3D"100%" style=3D"width:100%;">
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=09=09=09=09<![endif]-->
=09=09=09
=09=09=09=09<!--[if mso]>
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=09=09=09=09<![endif]-->
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;float: left;" width=3D"100%" class=3D"mc=
nTextContentContainer">
                    <tbody><tr>

                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding: 0px 18px 9px;text-align: left;mso-line-height-rule: exactly;-=
ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;word-break: break=
-word;color: #212121;font-family: 'Helvetica Neue'=2C Helvetica=2C Arial=
=2C Verdana=2C sans-serif;font-size: 15px;line-height: 150%;">



<h2 class=3D"mc-toc-title" style=3D"display: block;margin: 0;padding: 0;co=
lor: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=
=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-height=
: 125%;letter-spacing: normal;text-align: left;"><a href=3D"https://alsnew=
stoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D=
6f55856f58&e=3D006462e992" target=3D"_blank" style=3D"mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #084c61;font-weight: normal;text-decoration: underline;">The ongoing tur=
nover of ALS caregivers is challenging to manage</a></h2>
<span style=3D"color:#033443"><em>By Kristin Neva on </em></span><em>01/08=
/2026</em><br>
<span style=3D"color:#212121"><a href=3D"https://alsnewstoday.us5.list-man=
age.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3Dd9b656e3a5&e=3D006462e992" title=3D"The ongoing turnover of ALS caregivers is challenging to=
 manage" rel=3D"nofollow" style=3D"mso-line-height-rule: exactly;-ms-text-=
size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61;font-weigh=
t: normal;text-decoration: underline;"><img width=3D"800" src=3D"https://a=
lsnewstoday.com/wp-content/uploads/2020/09/kristinneva_joyfulsorrow-1024x3=
84.jpg" class=3D"webfeedsFeaturedVisual wp-post-image mcRssImage" alt=3D"M=
ain graphic for &quot;Joyful Sorrow&quot; column by Kristin Neva" style=3D=
"max-width: 100%;width: 100%;padding-bottom: 0;display: inline;vertical-al=
ign: bottom;border: 0;height: auto;outline: none;text-decoration: none;-ms=
-interpolation-mode: bicubic;" link_thumbnail=3D"1" decoding=3D"async" loa=
ding=3D"lazy" srcset=3D"https://alsnewstoday.com/wp-content/uploads/2020/0=
9/kristinneva_joyfulsorrow-1024x384.jpg 1024w=2C https://alsnewstoday.com/=
wp-content/uploads/2020/09/kristinneva_joyfulsorrow-300x113.jpg 300w=2C ht=
tps://alsnewstoday.com/wp-content/uploads/2020/09/kristinneva_joyfulsorrow=
-768x288.jpg 768w=2C https://alsnewstoday.com/wp-content/uploads/2020/09/k=
ristinneva_joyfulsorrow-1200x450.jpg 1200w=2C https://alsnewstoday.com/wp-=
content/uploads/2020/09/kristinneva_joyfulsorrow.jpg 1400w" sizes=3D"(max-=
width: 800px) 100vw=2C 800px" data-wp-pid=3D"37676" border=3D"0"></a><p st=
yle=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-text-si=
ze-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121;font-family:=
 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size=
: 15px;line-height: 150%;text-align: left;">=E2=80=9CI feel like crying=2C=
=E2=80=9D I wrote in my journal after a second caregiver decided to leave=
 in December. =E2=80=9CI can do 18 hours a day on duty=2C but I need to sl=
eep sometimes.=E2=80=9D For a few months=2C we had had a reliable team of=
 nighttime caregivers for my husband=2C Todd=2C who has ALS. But just [&#=
8230;]</p>
<p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121;font-fa=
mily: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font=
-size: 15px;line-height: 150%;text-align: left;">The post <a href=3D"https=
://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee=
792&id=3Dea7f038caf&e=3D006462e992" style=3D"mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61=
;font-weight: normal;text-decoration: underline;">The ongoing turnover of=
 ALS caregivers is challenging to manage</a> appeared first on <a href=3D"=
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D7f14cc9424&e=3D006462e992" style=3D"mso-line-height-rule: e=
xactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #0=
84c61;font-weight: normal;text-decoration: underline;">ALS News Today</a>.=
</p></span>
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<h2 class=3D"mc-toc-title" style=3D"display: block;margin: 0;padding: 0;co=
lor: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=
=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-height=
: 125%;letter-spacing: normal;text-align: left;"><a href=3D"https://alsnew=
stoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D=
c2b7c06fff&e=3D006462e992" target=3D"_blank" style=3D"mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #084c61;font-weight: normal;text-decoration: underline;">Shionogi streng=
thens rare disease strategy with planned Radicava deal</a></h2>
<span style=3D"color:#033443"><em>By Margarida Maia=2C PhD on </em></span>=
<em>01/08/2026</em><br>
<span style=3D"color:#212121"><a href=3D"https://alsnewstoday.us5.list-man=
age.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3Dc6d59c1edc&e=3D006462e992" title=3D"Shionogi strengthens rare disease strategy with planned=
 Radicava deal" rel=3D"nofollow" style=3D"mso-line-height-rule: exactly;-m=
s-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61;fon=
t-weight: normal;text-decoration: underline;"><img width=3D"700" src=3D"ht=
tps://alsnewstoday.com/wp-content/uploads/2023/06/collab-handshake.png" cl=
ass=3D"webfeedsFeaturedVisual wp-post-image mcRssImage" alt=3D"A illustrat=
ion of collaboration shows a close-up of two people's hands clasped togeth=
er in a handshake." style=3D"max-width: 100%;width: 100%;padding-bottom: 0=
;display: inline;vertical-align: bottom;border: 0;height: auto;outline: no=
ne;text-decoration: none;-ms-interpolation-mode: bicubic;" link_thumbnail=
=3D"1" decoding=3D"async" loading=3D"lazy" srcset=3D"https://alsnewstoday.=
com/wp-content/uploads/2023/06/collab-handshake.png 700w=2C https://alsnew=
stoday.com/wp-content/uploads/2023/06/collab-handshake-380x190.png 380w" s=
izes=3D"(max-width: 700px) 100vw=2C 700px" data-wp-pid=3D"85409" border=3D=
"0"></a><p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121=
;font-family: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-se=
rif;font-size: 15px;line-height: 150%;text-align: left;">Tanabe Pharma pla=
ns to establish a new U.S.-based company to hold the global rights to Radi=
cava and Radicava ORS=2C two edaravone formulations approved to treat amyo=
trophic lateral sclerosis (ALS)=2C which Shionogi plans to acquire and ope=
rate as a wholly owned subsidiary. =E2=80=9CWe are pleased to welcome Radi=
cava to Shionogi=2C=E2=80=9D Isao Teshirogi=2C PhD=2C Shionogi=E2=80=99s p=
resident and [&#8230;]</p>
<p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121;font-fa=
mily: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font=
-size: 15px;line-height: 150%;text-align: left;">The post <a href=3D"https=
://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee=
792&id=3D99895f8e13&e=3D006462e992" style=3D"mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61=
;font-weight: normal;text-decoration: underline;">Shionogi strengthens rar=
e disease strategy with planned Radicava deal</a> appeared first on <a hre=
f=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386=
bd00ea57ee792&id=3Da6e0aa2c2e&e=3D006462e992" style=3D"mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;colo=
r: #084c61;font-weight: normal;text-decoration: underline;">ALS News Today=
</a>.</p></span>
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text-align: center;text-decoration: none;color: #084C61;mso-line-height-ru=
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                        <td valign=3D"top" class=3D"mcnTextContent" style=
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<h3 class=3D"null" style=3D"display: block;margin: 0;padding: 0;color: #21=
2121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C serif;=
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ter-spacing: normal;text-align: left;">More Recent Articles:</h3>
<a rel=3D"nofollow" target=3D"_blank" href=3D"https://alsnewstoday.us5.lis=
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=09=09=09=09</td>
=09=09=09=09<![endif]-->

=09=09=09=09<!--[if mso]>
=09=09=09=09</tr>
=09=09=09=09</table>
=09=09=09=09<![endif]-->
            </td>
        </tr>
    </tbody>
</table></td>
                                        </tr>
                                    </table>
                                    <!--[if (gte mso 9)|(IE)]>
                                    </td>
                                    </tr>
                                    </table>
                                    <![endif]-->
                                </td>
                            </tr>
                            <tr>
                                <td align=3D"center" valign=3D"top" id=3D"=
templateFooter" style=3D"background: #transparent none no-repeat center/co=
ver;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;background-color: #transparent;background-image: none;ba=
ckground-repeat: no-repeat;background-position: center;background-size: co=
ver;border-top: 0;border-bottom: 0;padding-top: 9px;padding-bottom: 9px;">
                                    <!--[if (gte mso 9)|(IE)]>
                                    <table align=3D"center" border=3D"0" c=
ellspacing=3D"0" cellpadding=3D"0" width=3D"600" style=3D"width:600px;">
                                    <tr>
                                    <td align=3D"center" valign=3D"top" wi=
dth=3D"600" style=3D"width:600px;">
                                    <![endif]-->
                                    <table align=3D"center" border=3D"0" c=
ellpadding=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"templateContain=
er" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rsp=
ace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;max-wid=
th: 600px !important;">
                                        <tr>
                                            <td valign=3D"top" class=3D"fo=
oterContainer" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust=
: 100%;-webkit-text-size-adjust: 100%;"><table border=3D"0" cellpadding=3D=
"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnBoxedTextBlock" style=3D"=
min-width: 100%;border-collapse: collapse;mso-table-lspace: 0pt;mso-table-=
rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
    <!--[if gte mso 9]>
=09<table align=3D"center" border=3D"0" cellspacing=3D"0" cellpadding=3D"0=
" width=3D"100%">
=09<![endif]-->
=09<tbody class=3D"mcnBoxedTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnBoxedTextBlockInner" style=3D"m=
so-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-=
adjust: 100%;">

=09=09=09=09<!--[if gte mso 9]>
=09=09=09=09<td align=3D"center" valign=3D"top" ">
=09=09=09=09<![endif]-->
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" width=3D"100%" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;float: left;" class=3D"mcnBoxedTextConten=
tContainer">
                    <tbody><tr>

                        <td style=3D"padding-top: 9px;padding-left: 18px;p=
adding-bottom: 9px;padding-right: 18px;mso-line-height-rule: exactly;-ms-t=
ext-size-adjust: 100%;-webkit-text-size-adjust: 100%;">

                            <table border=3D"0" cellspacing=3D"0" class=3D=
"mcnTextContentContainer" width=3D"100%" style=3D"min-width: 100% !importa=
nt;background-color: #084C61;border-collapse: collapse;mso-table-lspace: 0=
pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adju=
st: 100%;">
                                <tbody><tr>
                                    <td valign=3D"top" class=3D"mcnTextCon=
tent" style=3D"padding: 18px;color: #FFFFFF;font-family: Helvetica;font-si=
ze: 16px;font-weight: normal;text-align: center;mso-line-height-rule: exac=
tly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;word-break:=
 break-word;line-height: 125%;">
                                        <h3 class=3D"null" style=3D"text-a=
lign: center;display: block;margin: 0;padding: 0;color: #212121;font-famil=
y: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C serif;font-size: 17px=
;font-style: normal;font-weight: bold;line-height: 125%;letter-spacing: no=
rmal;"><span style=3D"color:#FFFFFF">Discuss these topics and much more on=
 the ALS&nbsp;News Today forums</span></h3>

<center>
<table border=3D"0" cellpadding=3D"" cellspacing=3D"0" class=3D"mcnButtonB=
lock" style=3D"min-width: 100%;border-collapse: collapse;mso-table-lspace:=
 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-ad=
just: 100%;" width=3D"100%">
=09<tbody class=3D"mcnButtonBlockOuter">
=09=09<tr>
=09=09=09<td align=3D"center" class=3D"mcnButtonBlockInner" style=3D"paddi=
ng-top:0;padding-right: 18px;padding-bottom: 0px;padding-left: 18px;mso-li=
ne-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjus=
t: 100%;" valign=3D"top">&nbsp;
=09=09=09<table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" class=3D"=
mcnButtonContentContainer" style=3D"border-collapse: separate !important;b=
order-top-left-radius: 43px;border-top-right-radius: 43px;border-bottom-ri=
ght-radius: 43px;border-bottom-left-radius: 43px;background-color: #fdba53=
;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-w=
ebkit-text-size-adjust: 100%;">
=09=09=09=09<tbody>
=09=09=09=09=09<tr>
=09=09=09=09=09=09<td align=3D"center" class=3D"mcnButtonContent" style=3D=
"font-family: &quot;Helvetica Neue&quot;=2C Helvetica=2C Arial=2C Verdana=
=2C sans-serif;font-size: 16px;padding: 10px;mso-line-height-rule: exactly=
;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" valign=3D"mid=
dle"><a class=3D"mcnButton " href=3D"https://alsnewstoday.us5.list-manage.=
com/track/click?u=3D52c64784d386bd00ea57ee792&id=3De5a3010e62&e=3D006462e992" style=3D"font-weight: bold;letter-spacing: normal;line-height: 100%;t=
ext-align: center;text-decoration: none;color: #084c61 ;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;disp=
lay: block;" target=3D"_blank" title=3D"Continue Reading">Join Now</a></td=
>
=09=09=09=09=09</tr>
=09=09=09=09</tbody>
=09=09=09</table>
=09=09=09</td>
=09=09</tr>
=09</tbody>
</table>
</center>

                                    </td>
                                </tr>
                            </tbody></table>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09<!--[if gte mso 9]>
=09=09=09=09</td>
=09=09=09=09<![endif]-->

=09=09=09=09<!--[if gte mso 9]>
                </tr>
                </table>
=09=09=09=09<![endif]-->
            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnTextBlock" style=3D"min-width: 100%;border-collapse: coll=
apse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100=
%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnTextBlockOuter">
        <tr>
            <td valign=3D"top" class=3D"mcnTextBlockInner" style=3D"paddin=
g-top: 9px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webki=
t-text-size-adjust: 100%;">
              =09<!--[if mso]>
=09=09=09=09<table align=3D"left" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" width=3D"100%" style=3D"width:100%;">
=09=09=09=09<tr>
=09=09=09=09<![endif]-->
=09=09=09
=09=09=09=09<!--[if mso]>
=09=09=09=09<td valign=3D"top" width=3D"600" style=3D"width:600px;">
=09=09=09=09<![endif]-->
                <table align=3D"left" border=3D"0" cellpadding=3D"0" cells=
pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
0%;-webkit-text-size-adjust: 100%;float: left;" width=3D"100%" class=3D"mc=
nTextContentContainer">
                    <tbody><tr>

                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding-top: 0;padding-right: 18px;padding-bottom: 9px;padding-left: 1=
8px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;word-break: break-word;color: #212121;font-family: 'Helv=
etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 12px=
;line-height: 125%;text-align: center;">

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<span style=3D"font-size:20px"><em><strong>Follow us on social media for a=
ccess to exclusive content!</strong></em></span>
                        </td>
                    </tr>
                </tbody></table>
=09=09=09=09<!--[if mso]>
=09=09=09=09</td>
=09=09=09=09<![endif]-->

=09=09=09=09<!--[if mso]>
=09=09=09=09</tr>
=09=09=09=09</table>
=09=09=09=09<![endif]-->
            </td>
        </tr>
    </tbody>
</table><table border=3D"0" cellpadding=3D"0" cellspacing=3D"0" width=3D"1=
00%" class=3D"mcnFollowBlock" style=3D"min-width: 100%;border-collapse: co=
llapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 1=
00%;-webkit-text-size-adjust: 100%;">
    <tbody class=3D"mcnFollowBlockOuter">
        <tr>
            <td align=3D"center" valign=3D"top" style=3D"padding: 9px;mso-=
line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adj=
ust: 100%;" class=3D"mcnFollowBlockInner">
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dth=3D"100%" class=3D"mcnFollowContentContainer" style=3D"min-width: 100%;=
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text-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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e-adjust: 100%;">
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                <tbody><tr>
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op: 9px;padding-right: 9px;padding-left: 9px;mso-line-height-rule: exactly=
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ce: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size=
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=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;">
                                    <!--[if mso]>
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ellspacing=3D"0" cellpadding=3D"0">
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                                    <![endif]-->

                                        <!--[if mso]>
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                                        <![endif]-->


                                            <table align=3D"left" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"display: inline;border=
-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-s=
ize-adjust: 100%;-webkit-text-size-adjust: 100%;float: left;">
                                                <tbody><tr>
                                                    <td valign=3D"top" sty=
le=3D"padding-right: 10px;padding-bottom: 9px;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcn=
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le-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;"=
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=3D"left" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 10px;=
padding-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;float: le=
ft;">
                                                                        <t=
body><tr>

                                                                         =
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lowIconContent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                                                                         =
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?u=3D52c64784d386bd00ea57ee792&id=3D57f7f58297&e=3D006462e992" target=3D"=
_blank" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;=
-webkit-text-size-adjust: 100%;"><img src=3D"https://cdn-images.mailchimp.=
com/icons/social-block-v2/outline-color-facebook-48.png" alt=3D"Facebook"=
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ion: none;-ms-interpolation-mode: bicubic;" height=3D"24" width=3D"24" cla=
ss=3D""></a>
                                                                         =
       </td>


                                                                        </=
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                                                                    </tbod=
y></table>
                                                                </td>
                                                            </tr>
                                                        </tbody></table>
                                                    </td>
                                                </tr>
                                            </tbody></table>

                                        <!--[if mso]>
                                        </td>
                                        <![endif]-->

                                        <!--[if mso]>
                                        <td align=3D"center" valign=3D"top=
">
                                        <![endif]-->


                                            <table align=3D"left" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"display: inline;border=
-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-s=
ize-adjust: 100%;-webkit-text-size-adjust: 100%;float: left;">
                                                <tbody><tr>
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le=3D"padding-right: 10px;padding-bottom: 9px;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcn=
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le-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;"=
>
                                                            <tbody><tr>
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=3D"left" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 10px;=
padding-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
                                                                    <table=
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" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;float: le=
ft;">
                                                                        <t=
body><tr>

                                                                         =
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lowIconContent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                                                                         =
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?u=3D52c64784d386bd00ea57ee792&id=3Dde8e6efa0f&e=3D006462e992" target=3D"=
_blank" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;=
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com/icons/social-block-v2/outline-color-twitter-48.png" alt=3D"Twitter" st=
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=3D""></a>
                                                                         =
       </td>


                                                                        </=
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                                                                    </tbod=
y></table>
                                                                </td>
                                                            </tr>
                                                        </tbody></table>
                                                    </td>
                                                </tr>
                                            </tbody></table>

                                        <!--[if mso]>
                                        </td>
                                        <![endif]-->

                                        <!--[if mso]>
                                        <td align=3D"center" valign=3D"top=
">
                                        <![endif]-->


                                            <table align=3D"left" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"display: inline;border=
-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-s=
ize-adjust: 100%;-webkit-text-size-adjust: 100%;float: left;">
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le=3D"padding-right: 10px;padding-bottom: 9px;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcn=
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le-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;"=
>
                                                            <tbody><tr>
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=3D"left" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 10px;=
padding-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;">
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" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspac=
e: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;float: le=
ft;">
                                                                        <t=
body><tr>

                                                                         =
       <td align=3D"center" valign=3D"middle" width=3D"24" class=3D"mcnFol=
lowIconContent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                                                                         =
           <a href=3D"https://alsnewstoday.us5.list-manage.com/track/click=
?u=3D52c64784d386bd00ea57ee792&id=3Db935fbe973&e=3D006462e992" target=3D"=
_blank" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;=
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com/icons/social-block-v2/outline-color-instagram-48.png" alt=3D"Instagram=
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tion: none;-ms-interpolation-mode: bicubic;" height=3D"24" width=3D"24" cl=
ass=3D""></a>
                                                                         =
       </td>


                                                                        </=
tr>
                                                                    </tbod=
y></table>
                                                                </td>
                                                            </tr>
                                                        </tbody></table>
                                                    </td>
                                                </tr>
                                            </tbody></table>

                                        <!--[if mso]>
                                        </td>
                                        <![endif]-->

                                        <!--[if mso]>
                                        <td align=3D"center" valign=3D"top=
">
                                        <![endif]-->


                                            <table align=3D"left" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"display: inline;border=
-collapse: collapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-s=
ize-adjust: 100%;-webkit-text-size-adjust: 100%;float: left;">
                                                <tbody><tr>
                                                    <td valign=3D"top" sty=
le=3D"padding-right: 10px;padding-bottom: 9px;mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" class=3D"mcn=
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" cellpadding=3D"0" cellspacing=3D"0" width=3D"100%" class=3D"mcnFollowCon=
tentItem" style=3D"border-collapse: collapse;mso-table-lspace: 0pt;mso-tab=
le-rspace: 0pt;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;"=
>
                                                            <tbody><tr>
                                                                <td align=
=3D"left" valign=3D"middle" style=3D"padding-top: 5px;padding-right: 10px;=
padding-bottom: 5px;padding-left: 9px;mso-line-height-rule: exactly;-ms-te=
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adjust: 100%;">

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tent" style=3D"padding: 18px;color: #FFFFFF;font-family: Helvetica;font-si=
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