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** The Web's Daily Resource for ALS News
------------------------------------------------------------


** In the 01/20/2026 edition:
------------------------------------------------------------

*
** New TDP-43-targeting antibodies may open a path for ALS treatment (http=
s://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57e=
e792&id=3Da818b72477&e=3D006462e992)
------------------------------------------------------------





** New TDP-43-targeting antibodies may open a path for ALS treatment (http=
s://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57e=
e792&id=3Dbf1beb9683&e=3D006462e992)
------------------------------------------------------------
By Andrea Lobo=2C PhD on 01/20/2026
https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00e=
a57ee792&id=3D34b6d4e931&e=3D006462e992

Mindwalk Holdings has identified and validated antibodies that selectively=
 target an abnormal form of the TDP-43 protein=2C which is found in about=
 97% of amyotrophic lateral sclerosis (ALS) cases and is also linked to ot=
her neurodegenerative diseases. The candidates include antibodies that cou=
ld potentially be given as a treatment=2C as well as intracellular antibod=
ies=2C or [=E2=80=A6]

The post New TDP-43-targeting antibodies may open a path for ALS treatment=
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                                        <a href=3D"https://us5.campaign-ar=
chive.com/?e=3D006462e992&u=3D52c64784d386bd00ea57ee792&id=3D8bc9e87cfc" tar=
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=09=09=09=09<table align=3D"left" border=3D"0" cellspacing=3D"0" cellpaddi=
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pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
lapse;mso-table-lspace: 0pt;mso-table-rspace: 0pt;-ms-text-size-adjust: 10=
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                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding-top: 0;padding-right: 18px;padding-bottom: 9px;padding-left: 1=
8px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;word-break: break-word;color: #212121;font-family: 'Helv=
etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 15px=
;line-height: 150%;text-align: left;">

                            <h3 style=3D"display: block;margin: 0;padding:=
 0;color: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Rom=
an'=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-hei=
ght: 125%;letter-spacing: normal;text-align: left;"><strong>The Web's Dail=
y Resource for ALS News</strong></h3>

<h4 style=3D"display: block;margin: 0;padding: 0;color: #212121;font-famil=
y: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C serif;font-size: 16px=
;font-style: normal;font-weight: bold;line-height: 125%;letter-spacing: no=
rmal;text-align: left;"><strong>In the 01/20/2026 edition:</strong></h4>


<ul>
=09<li style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-=
webkit-text-size-adjust: 100%;">
=09<h2 class=3D"null" style=3D"display: block;margin: 0;padding: 0;color:=
 #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C se=
rif;font-size: 17px;font-style: normal;font-weight: bold;line-height: 125%=
;letter-spacing: normal;text-align: left;"><span class=3D"mc-toc-title"><a=
 href=3D"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784=
d386bd00ea57ee792&id=3Dfd58d264d3&e=3D006462e992" target=3D"_blank" style=
=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;color: #084c61;font-weight: normal;text-decoration: unde=
rline;">New TDP-43-targeting antibodies may open a path for ALS treatment<=
/a></span></h2>
=09</li>
</ul>
<span style=3D"font-size:16px"><span style=3D"font-family:merriweather=2Cg=
eorgia=2Ctimes new roman=2Cserif"> </span></span>
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pacing=3D"0" style=3D"max-width: 100%;min-width: 100%;border-collapse: col=
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0%;-webkit-text-size-adjust: 100%;float: left;" width=3D"100%" class=3D"mc=
nTextContentContainer">
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                        <td valign=3D"top" class=3D"mcnTextContent" style=
=3D"padding-top: 0;padding-right: 18px;padding-bottom: 9px;padding-left: 1=
8px;mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;-webkit-text-=
size-adjust: 100%;word-break: break-word;color: #212121;font-family: 'Helv=
etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 15px=
;line-height: 150%;text-align: left;">

                            <div style=3D"text-align: left;"></div>

<h2 class=3D"mc-toc-title" style=3D"display: block;margin: 0;padding: 0;co=
lor: #212121;font-family: 'Merriweather'=2C Georgia=2C 'Times New Roman'=
=2C serif;font-size: 17px;font-style: normal;font-weight: bold;line-height=
: 125%;letter-spacing: normal;text-align: left;"><a href=3D"https://alsnew=
stoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D=
d56d8a91c5&e=3D006462e992" target=3D"_blank" style=3D"mso-line-height-rul=
e: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color=
: #084c61;font-weight: normal;text-decoration: underline;">New TDP-43-targ=
eting antibodies may open a path for ALS treatment</a></h2>
<span style=3D"color:#033443"><em>By Andrea Lobo=2C PhD on </em></span><em=
>01/20/2026</em><br>
<span style=3D"color:#212121"><a href=3D"https://alsnewstoday.us5.list-man=
age.com/track/click?u=3D52c64784d386bd00ea57ee792&id=3D722de12868&e=3D006462e992" title=3D"New TDP-43-targeting antibodies may open a path for ALS=
 treatment" rel=3D"nofollow" style=3D"mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61;font-we=
ight: normal;text-decoration: underline;"><img width=3D"700" src=3D"https:=
//alsnewstoday.com/wp-content/uploads/2022/08/Casein-Antibodies.png" class=
=3D"webfeedsFeaturedVisual wp-post-image mcRssImage" alt=3D"A group of ant=
ibodies is pictured." style=3D"max-width: 100%;width: 100%;padding-bottom:=
 0;display: inline;vertical-align: bottom;border: 0;height: auto;outline:=
 none;text-decoration: none;-ms-interpolation-mode: bicubic;" link_thumbna=
il=3D"1" decoding=3D"async" loading=3D"lazy" srcset=3D"https://alsnewstoda=
y.com/wp-content/uploads/2022/08/Casein-Antibodies.png 700w=2C https://als=
newstoday.com/wp-content/uploads/2022/08/Casein-Antibodies-380x190.png 380=
w" sizes=3D"(max-width: 700px) 100vw=2C 700px" data-wp-pid=3D"79091" borde=
r=3D"0"></a><p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: ex=
actly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #21=
2121;font-family: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C san=
s-serif;font-size: 15px;line-height: 150%;text-align: left;">Mindwalk Hold=
ings has identified and validated antibodies that selectively target an ab=
normal form of the TDP-43 protein=2C which is found in about 97% of amyotr=
ophic lateral sclerosis (ALS) cases and is also linked to other neurodegen=
erative diseases. The candidates include antibodies that could potentially=
 be given as a treatment=2C as well as intracellular antibodies=2C or [&#=
8230;]</p>
<p style=3D"margin: 10px 0;padding: 0;mso-line-height-rule: exactly;-ms-te=
xt-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #212121;font-fa=
mily: 'Helvetica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font=
-size: 15px;line-height: 150%;text-align: left;">The post <a href=3D"https=
://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00ea57ee=
792&id=3D30c04a8f77&e=3D006462e992" style=3D"mso-line-height-rule: exactl=
y;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color: #084c61=
;font-weight: normal;text-decoration: underline;">New TDP-43-targeting ant=
ibodies may open a path for ALS treatment</a> appeared first on <a href=3D=
"https://alsnewstoday.us5.list-manage.com/track/click?u=3D52c64784d386bd00=
ea57ee792&id=3Da67580c321&e=3D006462e992" style=3D"mso-line-height-rule:=
 exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;color:=
 #084c61;font-weight: normal;text-decoration: underline;">ALS News Today</=
a>.</p></span>
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00%" class=3D"mcnButtonBlock" style=3D"min-width: 100%;border-collapse: co=
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e-adjust: 100%;">
                                <a class=3D"mcnButton " title=3D"Continue=
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text-align: center;text-decoration: none;color: #084C61;mso-line-height-ru=
le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;disp=
lay: block;">Continue Reading</a>
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tly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;word-break:=
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                                        <h3 class=3D"null" style=3D"text-a=
lign: center;display: block;margin: 0;padding: 0;color: #212121;font-famil=
y: 'Merriweather'=2C Georgia=2C 'Times New Roman'=2C serif;font-size: 17px=
;font-style: normal;font-weight: bold;line-height: 125%;letter-spacing: no=
rmal;"><span style=3D"color:#FFFFFF">Discuss these topics and much more on=
 the ALS&nbsp;News Today forums</span></h3>

<center>
<table border=3D"0" cellpadding=3D"" cellspacing=3D"0" class=3D"mcnButtonB=
lock" style=3D"min-width: 100%;border-collapse: collapse;mso-table-lspace:=
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;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;" valign=3D"mid=
dle"><a class=3D"mcnButton " href=3D"https://alsnewstoday.us5.list-manage.=
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le: exactly;-ms-text-size-adjust: 100%;-webkit-text-size-adjust: 100%;disp=
lay: block;" target=3D"_blank" title=3D"Continue Reading">Join Now</a></td=
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=09=09=09=09<!--[if gte mso 9]>
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=09=09=09=09<!--[if gte mso 9]>
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=09=09=09=09<![endif]-->
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etica Neue'=2C Helvetica=2C Arial=2C Verdana=2C sans-serif;font-size: 12px=
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=09=09=09=09<!--[if mso]>
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                                        <!--[if mso]>
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                                        <![endif]-->

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                                        <!--[if mso]>
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                                                                         =
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                                                                         =
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                                                                         =
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                                                                        </=
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                                                                    </tbod=
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                                                                </td>
                                                            </tr>
                                                        </tbody></table>
                                                    </td>
                                                </tr>
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                                        <!--[if mso]>
                                        </td>
                                        <![endif]-->

                                        <!--[if mso]>
                                        <td align=3D"center" valign=3D"top=
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                                        <![endif]-->


                                            <table align=3D"left" border=
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                                                                         =
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lowIconContent" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjus=
t: 100%;-webkit-text-size-adjust: 100%;">
                                                                         =
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?u=3D52c64784d386bd00ea57ee792&id=3D1e482722a8&e=3D006462e992" target=3D"=
_blank" style=3D"mso-line-height-rule: exactly;-ms-text-size-adjust: 100%;=
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                                                                         =
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                                                                        </=
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                                                                    </tbod=
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                                                                </td>
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                                                        </tbody></table>
                                                    </td>
                                                </tr>
                                            </tbody></table>

                                        <!--[if mso]>
                                        </td>
                                        <![endif]-->

                                        <!--[if mso]>
                                        <td align=3D"center" valign=3D"top=
">
                                        <![endif]-->


                                            <table align=3D"left" border=
=3D"0" cellpadding=3D"0" cellspacing=3D"0" style=3D"display: inline;border=
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                                                                        <t=
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t: 100%;-webkit-text-size-adjust: 100%;">
                                                                         =
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?u=3D52c64784d386bd00ea57ee792&id=3D2626ee0d18&e=3D006462e992" target=3D"=
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